
The 2nd International Electronic Conference on Biomolecules: Biomacromolecules and the Modern World Challenges
Part of the International Electronic Conference on Biomolecules series
1–15 Nov 2022
Proteins, Carbohydrates, Nucleic Acids, Lipids, Ecology, Health, Technology
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- Event Details
IECBM 2022 is closed. Thanks for your participation.
You could download your certificate from your sciforum account.
See you in the next edition.
Welcome from the Chair
Dear Colleagues,
It is with great enthusiasm that we announce the 2nd International Electronic Conference on Biomolecules: Biomacromolecules and the Modern World Challenges (IECBM2022). The conference is organized by the MDPI open-access journal Biomolecules (Impact Factor 6.064), and will be held online from 1-15 November 2022.
This conference will provide leading scientists working in the field with an online platform on which to share their latest research and engage in exciting discussions. The main topics and sessions of the conference are:
Biomacromolecules: Proteins;
Biomacromolecules: Carbohydrates;
Biomacromolecules: Nucleic Acids;
Biomolecules: Lipids.
This online event will bring together researchers from all over the world with no concerns of travel or other related expenditures. Participation and “attendance” to the IECBM2022 are FREE of charge.
The conference invites submissions for abstracts that will be reviewed by the conference committee. The authors of accepted contributions will be invited to submit a conference paper along with a slide or poster presentation of their work. All participants will have the opportunity to examine, explore, and critically engage with research findings published in Sciforum during the conference.
After the conference, all accepted papers will be published in the proceedings of this e-conference within a dedicated issue of the MDPI journal Biology and Life Sciences Forum. In addition, all participants will be encouraged to submit a full paper to one dedicated Special Issue in Biomolecules with a 20% discount on the article processing charges (APC).
We hope that you will join this e-conference to exchange ideas, start fruitful collaborations, and make this edition a success.
Kind regards,
Prof. Dr. Vladimir N. Uversky, PhD, DSc, FRSB, FRSC
List of accepted submissions (53)
Id | Title | Authors | Presentation Video | Presentation Pdf | |||||||||||||||||||||||||||||||||||||
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sciforum-064034 | Graphene: A new material for wound healing | , , |
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One of the hot topics in medical research involves using new materials for repairing human tissues. Graphene and its derivatives (which would be abbreviated as graphene in the following text for simplicity) happens to be one such novel material and has excellent properties due to ability to help regenerate tissues. This could be potentially useful for tissue engineering, and skin/muscle/nerve/bone/cartilage repair. Wound healing in eczema, bed sores or burning accidents have a high risk of bacterial infection, and some graphene materials have shown to provide good therapeutic efficacy in the improvement of wound healing with new dressing materials. The mechanism of wound healing might be due to its anti-bacterial properties, immunomodulatory effect, anti-inflammatory effect as well as angiogenic properties. The reason behind this unique properties could be its lack of cytotoxicity, its compatibility with biological material in terms of adhesiveness, and its lack of inhibition of healthy cell migration. Graphene could also have some antibacterial properties which might be due to its dehydrating properties or the ability of some functional groups to generate free radicals that kill pathogenic bacteria. The biocompatibility could be demonstrated by examination of the adhesion of fibroblasts cell lines and the morphology of their filopodia (or the feet). While many model systems concentrate on skin repair and wound healing, the use of graphene is not limited to skin cells: A human stem cell model has also been used to mimic cell regeneration from acute myocardial infarction (MI) using graphene in the form of hydrogels. This model has established the enhanced cell survival rate, increased expression of pro-inflammatory factors, factors that aid in the formation of new blood vessels, and early cardiogenic biomarkers, using graphene quantum dots as a soft injectable hydrogel for heart regenerative function after MI. The study of graphene and graphene-based materials on inflammatory biomarkers and acute phase proteins will be the subject of investigation in this review. |
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sciforum-064851 | Impact of different cross-linking agents on functional, rheological, and structural properties of talipot palm starch: A non-conventional source of stem starch | , | N/A |
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Talipot palm (Corypha umbraculifera L .) is a non-conventional source of stem starch with a starch yield of 76%. Talipot starch was cross-linked with epichlorohydrin (EPS) and phosphoric acid (PS), significantly altered the functional, pasting, rheological, and structural properties. Amylose content of talipot starch was significantly decreased by cross-linking, and it increased the relative crystallinity. The swelling power of talipot starch was increased in EPS; however, it was decreased in PS. A similar trend was observed in the pasting profile, and EPS has higher peak and final viscosities. The cross-linking with epichlorohydrin and phosphoric acid significantly decreased the pasting temperature of talipot starch. The native starch gel has a hardness of 45.54 N, which was increased to 149.69 N in EPS, whereas it decreased to 13.62 N in PS. The paste clarity of all the samples was found to be decreased during cold storage. As compared to the native, both EPS and PS exhibited high paste clarity. The percentage syneresis was considerably decreased in cross-linked starches. The magnitude of both G’ and G” was significantly changed by cross-linking. EPS exhibited increased G’ and G” values, whereas it decreased in PS. |
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sciforum-060269 | Coaxial wet-spun fibers loaded with AAPV – a viable option for chronic wound healing |
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Sílvia Pereira-Lima ,
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Chronic wounds (CW) are a worldwide concern, causing serious strives on the health and quality of patients’ life. In CW, human neutrophil elastase (HNE) enzyme gets highly expressed during inflammation, reaching abnormally elevated concentrations. Additionally, prevalence of Staphylococcus aureus-induced infections remains very high and difficult to treat. Considering these phenomena, a drug delivery system made of co-axial wet-spun fibers, loaded with the tetrapeptide Ala-Ala-Pro-Val (AAPV, a known inhibitor of HNE activity) and N-carboxymethyl chitosan (NCMC, responsive to neutral-basic pH’s, characteristic of CW and endowed with antibacterial features), was proposed. AAPV was synthesized by solid-phase peptide synthesis, whereas NCMC was synthesized from low molecular weight chitosan in a chloroacetic acid mixture. HNE inhibition tests were conducted to establish the AAPV IC50 in 1.50 µg/mL and the NCMC minimum bactericidal concentration (MBC) against S. aureus in 6.40 mg/mL. These determinations were used to establish fiber loading amounts. Core-shell structures were produced with 10% w/v polycaprolactone (PCL) at the core and 2% w/v sodium alginate (SA) solutions at the shell. NCMC was mixed with SA at 2xMBC so neutral-basic pH-triggered solubility (characteristic of CW) would allow pores to be opened in the outer layer for accessing the core, where AAPV was combined with PCL. Fourier-transform infrared spectroscopy and brightfield microscopy were used to confirm the presence of the four components on the fibers and the co-axial architecture, respectively. Fibers presented maximum elongations of over 100%. Release kinetics studies conducted via UV-visible absorption spectroscopy mapped NCMC liberation overtime but were uncapable of detecting AAPV, since polymer degradation masked AAPV absorption peaks. Time-kill kinetics studies against S. aureus demonstrated the effectiveness of NCMC in eliminating this bacterium, particularly after 6 h of incubation. On its turn, AAPV guaranteed HNE inhibition. Data demonstrated the potential of SA-NCMC-PCL-AAPV co-axial systems to work as stepwise, pH-triggered delivery platforms. |
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sciforum-060962 |
Comparative Analyses of the Gelsolin Homology Domains of Gelsolin and Flightless-I
, Réka Pintér ,
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Andrea Teréz Vig ,
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Veronika Takács-Kollár ,
Submitted: 01 Apr 2022 Abstract: Show Abstract |
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Réka Pintér ,
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Andrea Teréz Vig ,
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Veronika Takács-Kollár ,
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Flightless-I is a unique member of the gelsolin superfamily alloying six gelsolin homology (GH) domains and leucine-rich repeats. Flightless-I is an established regulator of the actin cytoskeleton. However, its biochemical activities in actin dynamics regulation are still largely elusive. To better understand its biological functioning, we studied Flightless-I by in vitro fluorescence spectroscopy and single filament TIRF microscopy approaches. We found that Flightless-I inhibits actin assembly by high-affinity (∼ nM) filament barbed end capping, moderately facilitates nucleation by low-affinity (∼ µM) monomer binding and does not sever actin filaments in vitro. Flightless-I was found to interact with actin and affect actin dynamics in a calcium-independent fashion. Notably, our functional analyses indicate that GSN and Flightless-I respond to calcium differently implying different conformational characteristics of the GH domains in the two proteins. Bioinformatics analyses predict that the sequence elements responsible for calcium activation of GSN are not conserved in the GH domains of Flightless-I. Consistently, the use of the hydrophobic fluorescent dye (8-anilinonaphthalene-1-sulfonic acid; ANS) revealed that unlike that of GSN the conformational behavior of the GH domains Flightless-I was not significantly affected by calcium-binding. Altogether, our work reveals different calcium-response and predicts distinct modes of activation of GSN and Flightless-I.
New National Excellence Program of the Ministry for Innovation and Technology ÚNKP-21-3-II-PTE-997 (PG), University of Pécs, Medical School, KA-2021-30 (AV). We thank József Mihály (Institute of Genetics, Biological Research Centre) for the Flightless-I plasmids and Robert C. Robinson (Okoyama University) for the GSN plasmid. |
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sciforum-064393 | Genetically encoded fluorescent probes for imaging of intracellular localization and activity of SARS-CoV-2 proteins | , , | N/A |
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Since December 2019, the problem caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has grown to a global threat. The search for new treatment strategies is strongly associated with both fundamental research on mechanisms of virus life cycle and development of new screening platforms for anti-viral drug candidates. In this project we labelled SARS-CoV-2 membrane proteins M, E, S and studied their localization in mammalian cell compartments using fluorescent microscopy. We tested N- and C-oriented sensor designs and different fluorescent proteins. Also, we successfully visualized the early stages of M protein transport in real time. We found that M protein localizes in cell lysosomes, which supports the recent hypothesis that β-coronaviruses use lysosomal organelles for egress instead of traditional Golgi-mediated secretory pathway. Further we plan to study interactions between M, E and S using the FRET method. In addition, we developed several types of FRET-based and translocational sensors to track SARS-CoV-2 PLpro protease and measure its activity in living cells. Preliminary experiments showed the expected increase in donor fluorescence after proteolysis of PLpro site between the FRET-pair. Results of the current project will provide unique information on spatial-temporal dynamics and interaction between SARS-CoV-2 membrane proteins during the viral lifecycle. The developed system for real-time visualization of PLpro activity can potentially serve as a basis for safe cell antiviral drug screening platforms. The proposed strategy for studying viral proteins combines two important properties. Firstly, research is conducted on human living cells, which is closely approximated to native conditions in contrast to in vitro experiments. Secondly, the experimental system lacks interaction with a functional virus which makes it completely safe for the researcher. |
Conference Secretariat
Ms. Sienna Tian
Ms. Billie Jiao
Ms. Yufei Shi
Ms. Sara Wang
Ms. Letty Zhu
MDPI Branch Office, Beijing
E-mail: [email protected]
Event Chair

Department of Molecular Medicine, University of South Florida, USA
Vladimir Uversky is Professor at the College of Molecular Medicine, University of South Florida. He is a biophysicist and obtained his PhD and Doctor of Science (DSc) in Physics and Mathematics at the Moscow Institute of Physics and Technology (1991) and at the Institute Experimental and Theoretical Biophysics, Russian Academy of Sciences (1998), respectively. He spent his early career investigating protein folding at the Institute of Protein Research and the Institute for Biological Instrumentation (Russia). In 1998, he moved to the University of California Santa Cruz to work on protein folding, misfolding, and protein intrinsic disorder. In 2004, he joined the Indiana School of Medicine and, in 2010, the University of South Florida, where he has since been continuing his studies on protein folding, misfolding, and intrinsically disordered proteins. Prof. Vladimir Uversky has authored over 980 scientific publications, edited numerous books, and is also serves as the editor of several scientific journals. He was included in Thomson Reuters list of Highly Cited Researchers in 2014-2020.
Event Committee

Research Director, ISOF, Consiglio Nazionale delle Ricerche, Italy
Interests: free radical chemistry; biomimetic chemistry; organic synthesis; reaction mechanism; analytical protocols for biomarkers of radical stress; oxidative DNA damage; lipid modification; fatty acid-based lipidomics

Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC), INRA USC1328, Université ď Orléans, France
Interests: chemistry of natural products; analytical methods; HPLC; LC-MS; polyphenols (lignans, flavonoids, phenolic acids); ethnopharmacology; history of pharmacy

Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, China
Interests: novel therapeutic antibodies development; venom-based peptide & natural biomolecule prototype drugs development; cancer biomarkers & immunotherapy markers discovery for prognostic and therapeutic validation

School of Systems Biology and The Krasnow Institute for Advanced Study, George Mason University, USA
Interests: multiscale systems biology; computational biology; bioinformatics; cardiac physiology; immunology; mitochondria; cellular signaling; neuroscience; algorithms; HPC

Center for RNA Medicine, Department of Clinical Medicine, Aalborg University, Denmark
Interests: bioinformatics; cardiovascular system; circRNA; database; epitranscriptomics; lncRNA; miRNA; non-coding RNA

Department of Nutrition and Food Science, University of Granada, Campus of Cartuja, Spain
Interests: antioxidants; natural product chemistry; antioxidant activity; phytochemicals; lipids; lipid oxidation
Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON K7L 3N6, Canada
Interests: immunology; COVID-19 and ACE2 receptor; cancer; inflammation; TLR receptor; Trk receptor; GPCR signaling; insulin receptor; glycosylation; NEU1 sialidase
CSIC Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Santander, Spain
Interests: RAS; ERK; MAP kinases; scaffold proteins; signalling spatial regulation
Department of Chemistry, University of Coimbra, 3004 - 535 Coimbra, Portugal
Interests: transport properties; thermodynamic properties; electrolytes; polyelectrolytes; polymers; carbohydrates; drugs; carriers; dental alloys; corrosion
Call for Abstracts
The 2nd International Electronic Conference on Biomolecules will be held from 1-15 November, 2022. IECBM aims to promote and advance the exciting and rapidly changing field of biomacromolecules and the modern world challenges. All abstracts and presentations will be held online at https://iecbm2022.sciforum.net/.
Topics of interest include, but are not limited to:
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Biomacromolecules: Proteins (Session A);
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Biomacromolecules: Carbohydrates (Session B);
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Biomacromolecules: Nucleic Acids (Session C);
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Biomolecules: Lipids (Session D).
The conference will be completely free of charge—both to attend and for scholars to upload and present their latest work on the conference platform. There will also be the possibility to submit selected papers to the journal Biomolecules ( ISSN: 2218-273X; Impact Factor: 6.064) with a 20% discount on the APCs.
IECBM 2022 offers you the opportunity to participate in this international, scholarly conference without having the concern or expenditure of travel—all you need is your computer and access to the Internet. We would like to invite you to “attend” this conference and present your latest work.
Abstracts (in English) should be submitted by 29 July 2022 online at https://iecbm2022.sciforum.net/. For accepted abstracts, the presentations can be submitted by 16 September 2022. The abstracts and presentations will be available on Sciforum for discussion during the time of the conference (1-15 November 2022) and will be then published in the Journal Biology and Life Sciences Forum.
We hope you will be able to join this exciting event and support us in making it a success. IECBM 2022 is organized and sponsored by MDPI, a scholarly open-access publisher based in Basel, Switzerland.
Instructions for Authors
Submissions should be made by authors online by registering with https://iecbm2022.sciforum.net/, and using the "New Submission" function once logged into the system.
- Scholars interested in participating in the conference can submit their abstract (about 200–300 words) online on this website until 29 July 2022.
- The Conference Committee will notify the acceptance of the abstract by 10 August 2022.
- If the abstract is accepted for this conference, the author will be invited to prepare a full description of their work in the form of a Poster/PowerPoint/Video Presentation (max. 5 minutes), until the submission deadline 9 September 2022. Authors will receive a notification about the acceptance of their presentations by 11 October 2022.
- The abstracts and presentations will be available on https://iecbm2022.sciforum.net/ for discussion and rating during the time of the conference, from 1-15 November 2022.
- All accepted abstracts+presentations will be published as one dedicated volume in MDPI Biology and Life Sciences Forum (ISSN: 2504-3900). Publication of the proceedings will be free of charge.
- The open-access journal Biomolecules (Impact Factor 6.064) will publish a conference Special Issue. Conference participants are encouraged to submit a full paper to the dedicated Special Issue and will receive a 20% discount on the Article Processing Charges (APC), in case their paper is accepted for publication after peer-review.
Submission of Manuscripts
Authors are encouraged to prepare a presentation in PowerPoint or similar software, to be displayed online along with the manuscript. Slides can be prepared the same way as for any traditional conference. They should be converted to PDF format before submission.
Authors are also encouraged to submit video presentations. This is an unique way of presenting your paper and discussing it with peers from all over the world. Video should be no longer than 5 minutes and prepared with one of the following formats: .mp4 / .webm / .ogg (max size: 250Mb). Videos should be submitted with a copy of the accepted abstract by 9 September 2022.
Posters will be available on this conference website during and after the event, participants will be able to ask questions and make comments about the posters. Authors that wish to present a poster must follow the following instructions: 1) The poster should be in PDF format; 2) The content of the poster should be a comprehensive presentation of your accepted submission; 3) No copyright issues with any elements in the poster. Posters should be submitted along with a copy of the accepted abstract by 9 September 2022.
All authors must disclose all relationships or interests that could inappropriately influence or bias their work. This should be conveyed in a separate "Conflict of Interest" statement preceding the "Acknowledgments" and "References" sections at the end of the manuscript. If there is no conflict, please state "The authors declare no conflict of interest." Financial support for the study must be fully disclosed under "Acknowledgments" section.
MDPI, the publisher of the Sciforum.net platform, is an open access publisher. We believe that authors should retain the copyright to their scholarly works. Hence, by submitting a communication paper to this conference, you retain the copyright of your paper, but you grant MDPI the non-exclusive right to publish this paper online on the Sciforum.net platform. This means you can easily submit your paper to any scientific journal at a later stage and transfer the copyright to its publisher (if required by that publisher).
Event Awards
The Sponsor Biomolecules offers one Best Contribution Award and one Best Poster Award to our participants.
The Awards
300 CHF + publication waiver in Biomolecules Journal
300 CHF
Terms and Conditions:
All formats of presentations will be eligible for the Best Contribution Award.
Evaluation Criteria:
- Originality / Novelty
- Significance of content
- Scientific soundness
- Interest to the readers
- English language and style
Evaluation Process:
- Each Evaluation Committee member will assess the criteria outlined above for each application.
- Presentations will be ranked from highest to the lowest total score.
- If two or more authors get the same score, further evaluation will be carried out.
- Winners will be announced online after the conference.